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The MPN-SAF was utilized to assess 14 disease-related symptoms on a level of 0 to 10 . In addition to the MPN-SAF total symptom rating , ratings for specific symptoms and sign clusters were determined. Basic safety The safety population included all patients who received at least one dosage of a scholarly study drug, including those who received no medication as standard therapy, if they underwent any postrandomization assessments or procedures. Adverse occasions were assessed according to the National Tumor Institute Common Terminology Criteria for Adverse Events, edition 3.0 . Statistical Evaluation The efficacy analysis for the secondary and primary end points was performed based on the intention-to-treat principle, with data from all patients who underwent randomization. Assessments of transformation and %age change from baseline included all individuals with baseline measurements; changes in individual indicator scores included only sufferers with baseline values greater than 0.