All the authors made the decision to send the manuscript for publication and assume responsibility for the precision and completeness of the data. The NAVIGATOR trial process comes in Supplementary Appendix 2. Study Participants Subjects were eligible for inclusion in the analysis if they had impaired glucose tolerance,3 a fasting plasma glucose concentration of in least 95 mg per deciliter but less than 126 mg per deciliter , and something or more cardiovascular risk factors or known coronary disease . Topics were excluded if they had unusual laboratory test outcomes or concomitant conditions which could interfere with the evaluation of the protection or efficacy of the study drug or if they had taken antidiabetic medication within the prior 5 years.11 Study Medication Participants were assigned randomly, with the use of an interactive voice-response phone system, to nateglinide, in a dose of 60 mg taken before foods three times daily, or placebo and, in a 2-by-2 factorial design, to placebo or valsartan.Incremental Value in Risk Prediction The addition of HDL cholesterol to a prognostic model for first cardiovascular events that included data on age, sex, smoking status, blood pressure, history of diabetes, and total cholesterol increased the C-index by 0., and Table S3 in the Supplementary Appendix). The further addition of information on a biomarker of inflammation to the C-index was increased by this model by 0.0039 with CRP amounts and by 0.0027 with fibrinogen levels , yielding a net reclassification improvement of 1 1.52 percent and 0.02 for both comparisons) . The corresponding ideals for the built-in discrimination index were 0.0036 and 0.0027. In analyses that limited the results to cardiovascular system disease, the mixed predictive value of total and HDL cholesterol was higher than that of either CRP or fibrinogen .