Biopsies were extracted from various regions of the prostate so that they can mirror just how biopsies are performed on live individuals. Almost thirty % of the prostates got cancer cells, and 43 % of those had been clinically significant cancers as defined by tissue characteristics. Cancer detection depended even more on the part of the prostate that was biopsied than on the amount of samples that were used.. Accurate prostate cancers diagnosis depends on biopsy location The area of the prostate that is biopsied may matter a lot more than the number of biopsy samples taken for accurately diagnosing prostate cancer, according to a study by researchers at SUNY Upstate Medical University.The two researchers – friends who 1st collaborated when Kobilka was a trainee in Lefkowitz's laboratory at Duke – shared the 2012 Nobel Prize in Chemistry for their discoveries involving the G-proteins coupled receptors , which are activated by signaling proteins to detect hormones, neurotransmitters, pain, light. In today’s work, the researchers utilized X-ray crystallography to develop an atom-scale image of among the principal signaling molecules that regulate GPCRs. This proteins is named beta-arrestin1, which, among other things, works to dim a cell's response to hormones such as adrenalin.