A close look at Accutane medication registry iPledge The Chicago Sun-Times on Monday examined the online FDA tracking data source iPledge, with which all people taking Roche’s acne medication Accutane much register to receive their prescriptions . FDA on Dec. 30, 2005, began to register physicians, prescription drug wholesalers, pharmacists and ladies into iPledge after an FDA advisory committee in March 2004 recommended the scheduled program. Under iPledge, women are required to submit two negative pregnancy tests before they are able to receive an initial prescription for Accutane, known generically as isotretinoin, and ladies must undergo a monthly pregnancy test before every refill, along with fulfilling additional conditions intended to reduce the chance of pregnancy .We then included in the model, as categorical variables,16 the presence or absence of being pregnant, asthma or another chronic pulmonary disease, and chronic heart failure; BMI higher than 35 versus 35 or less; race or ethnic group; and the presence or lack of any coexisting condition; and the type of influenza syndrome. A two-sided P worth of less than 0.05 was considered to indicate statistical significance, except in the multivariate model, where a P value of significantly less than 0.01 was thought to indicate statistical significance. Results We identified 856 patients with influenza A infection who were admitted to an ICU between June 1 and August 31, 2009.