The altered intention-to-treat analysis yielded identical results . Both FXI-ASO regimens met the prespecified criteria for noninferiority, and the 300-mg FXI-ASO regimen was superior to enoxaparin . In the band of patients who had the average factor XI level of 0.2 units per milliliter or lower, the incidence of the primary efficacy outcome was 5 percent . No affected person had a symptomatic pulmonary embolism, no patient had symptomatic deep-vein thrombosis in the follow-up period after venography. There were no deaths. Bleeding The principal safety result of clinically relevant bleeding occurred in 4 of 144 patients in the 200-mg FXI-ASO group, in 2 of 77 individuals in the 300-mg FXI-ASO group, and in 6 of 72 individuals in the enoxaparin group .While many widely-used pain therapies require repeat dosing for symptom alleviation, an individual administration of AYX1 gets the potential to avoid the development of pain before it begins, said Donald Manning, M.D., Ph.D., chief medical officer of Adynxx. The actual fact that the FDA provides granted Fast Track designation for the prevention of chronic pain recognizes an important aspect of the unique profile of AYX1, which we believe will transform the treatment of post-surgical pain. .. U.S. Fight Deaths Declined Under ‘Golden Hour Policy’: Study: – WEDNESDAY, Sept.