Adverse events were graded and classified in accordance to Common Terminology Criteria for Adverse Events, version 4.0. Patient-reported outcomes were assessed by using the European Organisation for Analysis and Treatment of Cancer quality-of-life core questionnaire ,16,17 the corresponding lung cancer module ,18 and the EuroQol Group 5-Dimension Self-Record Questionnaire .19 Statistical Analysis We estimated that with 229 occasions of progression or loss of life, the study would have 85 percent power to detect a 50 percent improvement in progression-free survival with crizotinib versus chemotherapy , at a one-sided alpha degree of 0.025.New cartilage which has good properties can be grown in particular by cultivating adult stem cells in combination with a small level of cells from the patient's have cartilage. In the long run this increases the odds of a cartilage implant achieving success, provided it is completed in time. They are the findings put forward by PhD college student Nicole Georgi, who did her study at the University of Twente's MIRA Institute for Biomechanical Technology and Complex Medicine. She is to receive her PhD on 22 March. Over a million people in holland have pain in their knees or hips due to osteoarthritis, i.e.