It modifies the implant, presenting a more acceptable surface area to the human tissue. The coating can be applied to any silicone implant in the final production step, ahead of packaging and sterilization simply; it does not alter the mechanical efficiency of the implant. Related StoriesJust think about it: Giving natural motion to a patient with quadriplegia The preclinical outcomes have been published in ADVANCED FUNCTIONAL Components. In this research surgeons and AMSilk researchers could show that the AMSilk spider silk coating significantly reduces the price of major post-operative problems, such as for example capsular fibrosis, capsular thickness, hardening, and inflammation.Gene expression was evaluated visually from RNA-sequence read alignments with the Integrative Genomics Viewer . Validation of Applicant Somatic STAT3 and Mutations Screening After exome sequencing, the candidate mutations were validated with the use of Sanger sequencing. For the STAT3 mutation screening, five primer pairs were made to cover the six exons encoding the Src homology 2 domain of STAT3 . Statistical Analysis All statistical analyses are described at length in the Supplementary Appendix. Results Somatic Mutations Recognized by Exome Sequencing in the Index Patient The index patient was a 70-year-old man with untreated typical T-cell large granular lymphocytic leukemia.